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Tablet Application

Tablet is a type of pharmaceutical dosage form made from a solid drug mixture of active pharmaceutical ingredients (APIs) and excipients through processes such as blending, granulation, and compression. It primarily consists of the active pharmaceutical ingredients (APIs) and excipients, which include fillers (such as lactose, microcrystalline cellulose), binders (such as polyvinylpyrrolidone), disintegrants (such as starch, cross-linked polyvinylpyrrolidone), and lubricants (such as magnesium stearate). These excipients are used to improve the physical properties of the tablet, such as flowability, compressibility, and disintegration.

The types of tablets include ordinary pressed tablets, coated tablets, sugar coated tablets, film coated tablets, enteric coated tablets, effervescent tablets, chewable tablets, multilayer tablets, dispersed tablets, sublingual tablets, oral lozenges, implant tablets, solution tablets, sustained-release tablets.

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The diameter of tablets ranges from 6 mm to 12 mm, and their thickness is typically between 2 mm and 5 mm. Different sizes can be chosen based on the drug's ingredients, characteristics, and application scenarios. Additionally, tablets can come in various shapes beyond the common round ones, including oval, square, rectangular, triangular, and biconvex (where the center is thicker and the edges are thinner).

In addition to single-color tablets, tablets can also be produced in two or three colors. This is often used for drugs with complex release mechanisms or those requiring multiple functionalities, such as extended-release, controlled-release, or multi-stage release tablets. Using double-die tablet presses or specially designed tablet presses, different active pharmaceutical ingredients (API) or excipients can be compressed into double-layered or triple-layered tablets.

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The tablet production line of s can be divided into the following steps:

1. Material preparation, this step involves preparing the various raw materials used to prepare the tablet, including active ingredients, excipients, fillers, lubricants.

2. In the pelletizing mixing step, the raw materials are mixed evenly and prepared into a granular or granular form as needed. If the wet granulation method is used, the raw material is mixed with an appropriate amount of solvent to form wet particles; If dry granulation is used, the raw material is pressed into larger particles. High Shear Granulator and Fluid bed Grannulator play a crucial role in this process.

3. Drying this step is for the tablet production line using the wet granulation method, wet particles need to be dried to remove water and make the particles dry and hard.

4. The dried particles may need to be screened or crushed to ensure that the particle size and particle size distribution meet the requirements.

5. In the tablet press step, the particles are placed in the tablet press and pressed into the shape of a tablet by high pressure. Molds of different shapes and sizes can be used as required. Among them, GPZK series, as a popular model, greatly improves the production efficiency in the tablet link and saves the production cost.

6. Coating, for some tablets such as certain confectionery, coating or coating treatment may be required to improve the appearance, taste, stability or release characteristics of the tablet. In this link, due to product requirements, the products to be coated for tablets can choose BG-E Series coating machine, which is beautiful, high efficiency and low energy consumption.

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Tablet press machine

2018-07-16
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01

Table coating machine

2018-07-16
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Aligned is equipped with sophisticated equipment for each link and provides you with good service from all aspects. It not only saves time but also saves corresponding costs in production. It can better promote the production of products and ensure the quality of products while saving time and effort.

After completing tablet production, the Aligned team also provides packaging machines. There are various forms of tablet packaging, and the choice of the appropriate packaging form mainly depends on the nature, stability, convenience of use, and market demand of the tablets:
  • 1

    Blister Packaging

    Consists of transparent plastic blisters and a backing made of aluminum foil or plastic film, or aluminum blisters with aluminum foil backing. Each blister unit individually seals one tablet. This type provides excellent sealing and protection, preventing moisture, oxygen, and contaminants from entering. Visual packaging and easy access to the medication.
  • 2

    Bottle Packaging

    Tablets are packed in plastic or glass bottles, typically with moisture-proof and tamper-evident seals at the bottle mouth. This form has a larger capacity and can hold multiple tablets, and the bottle mouth can be specially designed to prevent children from opening it.
  • 3

    Strip Packaging

    Tablets are sealed in strip-shaped aluminum foil or plastic pouches, with each tablet or multiple tablets individually packed. This packaging offers good sealing, is convenient to carry, and is suitable for small quantities and a variety of medications, making it easy to distribute.
  • 4

    Tube Packaging

    Tablets are arranged in a tubular container, usually with a moisture-proof cap. This packaging provides excellent moisture resistance, making it particularly suitable for effervescent tablets or lozenges that are prone to moisture absorption.

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